FTO variation and early frontostriatal brain development in children
Authors' conclusion
These findings suggest that common genetic risk for obesity is associated with differences in early development of brain reward circuitry and argue for investigating dynamic relationships among genotype, brain, behavior, and weight throughout development.
Study context
- Population
- Children in RESONANCE, a longitudinal study of early brain development (102 female, 126 male)
- Participants
- 228 children
- Exposure
- FTO rs9939609 risk allele carriers vs no risk allele
- Outcome
- Growth trajectories of nucleus accumbens and frontal lobe volumes, total gray matter and white matter volume
- Follow-up
- Infancy through middle childhood
Methodological detailsfunctional concurrent regression models, MRI from infancy through middle childhood
- Functional concurrent regression models
- MRI from infancy through middle childhood
Main finding
As reported in the abstract
Nucleus accumbens volume (adjusted for total brain volume) · 750 to 2250 days (2-6 years)
- Greater nucleus accumbens volume in AA vs TT in the interval of 750 to 2250 days (2-6 years)
- Bootstrap pointwise 95% CI for regression coefficient functions
- Adjusted for sex, BMI z score and maternal education
Observational data: associations, not effects.
Original publication
FTO variation and early frontostriatal brain development in children. Obesity (Silver Spring). Published 10 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →