Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case–control study
Authors' conclusion
Our results indicate novel biomarkers, and suggest potential mechanisms, of fracture risk among older adults with T2D.
Study context
- Population
- Adults with T2D aged ≥ 50 years in the MURDOCK study, central North Carolina
- Participants
- 107 vs 210
- Comparison
- Incident fracture cases vs matched controls without incident fracture
- Fracture casesn = 107
- Matched controlsn = 210reference
- Outcome
- Association between incident fracture and metabolic profile (conventional metabolites, amino acids, acylcarnitines)
Methodological detailsmatched 1:2 by age, gender, race/ethnicity and BMI, conditional logistic regression, targeted metabolomics
- Matched 1:2 by age, gender, race/ethnicity and BMI
- Conditional logistic regression
- Targeted metabolomics
Main finding
As reported in the abstract
Association of metabolic factors with incident fracture
Amino acid factor E/QD/NRS (glutamine/glutamate, asparagine/aspartate, arginine, serine), adjusted OR
2.50 (1.36-4.63) (95% CI)
Non-esterified fatty acids, OR (95% CI), lower odds of fracture
0.17
0.03–0.87
Original publication
Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case–control study. Osteoporos Int. Published 26 April 2023. doi:10.
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