Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes
Authors' conclusion
People with T2D on GLP-1RA + MET treatment had better cognitive function and higher circulating levels of EPCs as compared with those on MET alone warranting further studies to understand the interrelationship between EPCs, GLP-RA treatment and cognitive health.
Study context
- Population
- Elderly adults with T2D treated with GLP-1 RA plus metformin or metformin alone for at least 12 months
- Participants
- 154 adults
- Exposure
- GLP-1 RA plus metformin vs metformin alone
- GLP-1RA + METn = 78
- METn = 76reference
- Outcome
- Cognitive function (MoCA, MMSE) and circulating endothelial progenitor cells (EPCs)
Main finding
As reported in the abstract
- Significantly higher MoCA and Mini-Mental State Examination (MMSE) scores with GLP-1RA + MET vs MET
- Higher levels of CD34+ CD133+, CD133+ KDR+ and CD34+ CD133+ KDR+ with GLP-1RA + MET vs MET
- CD34+ CD133+ KDR+ cell count was an independent predictor of higher MoCA, MMSE and Mini Nutritional Assessment (MNA) scores
Observational data: associations, not effects.
Original publication
Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes. Diabetes Res Clin Pract. Published 26 April 2023. doi:10.
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