Improved prediction of long-term kidney outcomes in people with type 2 diabetes by levels of circulating haematopoietic stem/progenitor cells
Main finding · Composite kidney outcomeResult — go to the resultAdjusted hazard ratio 0.69 95% CI 0.49–0.97Authors' conclusion
HSPC levels predict worsening of kidney function and improve the identification of individuals with type 2 diabetes and adverse kidney outcomes over and beyond a clinical risk score.
Study context
- Population
- Individuals with T2D with baseline circulating HSPC determination in 2004–2019, diabetes centre of the University Hospital of Padua; 67.8% men, mean age 65.6 yearsanalysed
- Participants
- 342 individuals
- Exposure
- High vs low circulating HSPC counts
- Low HSPCn = 171reference
- Outcome
- Composite of:
- New-onset macroalbuminuria
- Sustained ≥40% eGFR decline
- End-stage kidney disease
- Death from any cause
- Follow-up
- Median 6.7 years
Methodological detailssingle-centre, adjusted for known predictors of kidney disease
- Single-centre
- Adjusted for known predictors of kidney disease
Main finding
Composite kidney outcome
Adjusted hazard ratio
0.69
95% CI 0.49–0.97
High HSPCvs Low HSPC
adjusted HR 0.69 (95% CI 0.49–0.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline nephropathy prevalence45.0% vs 33.9%; greater with low HSPC | P = 0.036 |
eGFR decline and albuminuria · median follow-up 6.7 years
- Slower eGFR decline and similar increase in albuminuria with high vs low HSPC
Discrimination
- Adding HSPC to CKD Prognosis Consortium risk score significantly improved discrimination of future adverse kidney outcomes
Original publication
Improved prediction of long-term kidney outcomes in people with type 2 diabetes by levels of circulating haematopoietic stem/progenitor cells. Diabetologia. Published 15 September 2023. doi:10.
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