Major cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden
Authors' conclusion
Having a child diagnosed with type 1 diabetes in Sweden was not associated with MCE, but possibly with all-cause mortality. Further studies are needed to disentangle potential underlying mechanisms, and to investigate parental health outcomes across the full lifespan.
Study context
- Population
- Parents of 18,871 children diagnosed with T1D at <18 years in Sweden (born 1987–2020); median parental age at diagnosis 39.0 (mothers) and 41.0 (fathers) yearsparents of 18,871 children
- Exposure
- Parents of children with T1D vs matched parental controls
- Matched controlsn = 714,970reference
- Parental siblingsn = 12,497
- Outcome
- Incident MCE and all-cause death
- Follow-up
- Median 12 years, range 0-35
Methodological detailspopulation-based matched controls, parental sibling analysis, Cox proportional hazards regression
- Population-based matched controls
- Parental sibling analysis
- Cox proportional hazards regression
Main finding
As reported in the abstract
MCE · median follow-up 12 years (range 0-35)
No association between parenting a child with T1D and major cardiovascular events (MCE) in mothers: aHR
1.02 (0.90, 1.15) (95% CI)
No association between parenting a child with T1D and MCE in fathers: aHR
1.01 (0.94, 1.08) (95% CI)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause deathExposed fathersvs Control fathersSlightly increased hazard | 1.09 (1.01–1.18) | |
| All-cause deathExposed mothersvs Control mothers | 1.07 (0.96–1.20) | |
| IHDExposed mothersvs Control mothersIncreased hazard | 1.21 (1.05–1.41) | |
| IHDExposed fathersvs Control fathersNo corresponding signal | 0.97 (0.89–1.05) | |
| IHD in mothers, sibling analysisExposed mothersvs Parental siblingsDid not confirm the association | 1.01 (0.73–1.41) | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Estimate |
|---|---|
| All-cause death, sibling analysisExposed fathers vs Parental siblings | 1.12 (95% CI 0.90–1.38) |
| All-cause death, sibling analysisExposed mothers vs Parental siblings | 0.73 (95% CI 0.55–0.96) |
Original publication
Major cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden. Diabetologia. Published 26 June 2024. doi:10.
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