Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes
Authors' conclusion
BTMs are lower in newly diagnosed persons with T2D characterized by low insulin sensitivity.
Study context
- Population
- Newly diagnosed glucose-lowering treatment-naïve persons with T2D, Danish Centre for Strategic Research T2D cohort
- Participants
- 326 participants
- Exposure
- Insulinopenic vs classical vs hyperinsulinemic T2D phenotypes
- Outcome
- Fasting BTM levels (P1NP, CTX, osteocalcin) by T2D phenotype
Methodological detailsage- and gender-matched subgroups, phenotypes by homeostatic model assessment
- Age- and gender-matched subgroups
- Phenotypes by homeostatic model assessment
Main finding
As reported in the abstract
Median serum bone turnover markers (BTMs)
| Group | Value | CTX (ng/L) | Osteocalcin (μg/L) |
|---|---|---|---|
| Insulinopenic | median 52.3 (IQR 41.6–63.3) μg/L | 259.4 (IQR 163.4, 347.7) | 18.0 (IQR 14.4, 25.2) |
| Classical | median 41.4 (IQR 31.0–51.4) μg/L | 150.4 (IQR 103.5, 265.1) | 13.1 (IQR 10.0, 17.6) |
| Hyperinsulinemic | median 43.7 (IQR 32.3–57.3) μg/L | 163.3 (IQR 98.9, 273.1) | 15.7 (IQR 10.2, 20.8) |
Value
Insulinopenicmedian 52.3 (IQR 41.6–63.3) μg/L
Classicalmedian 41.4 (IQR 31.0–51.4) μg/L
Hyperinsulinemicmedian 43.7 (IQR 32.3–57.3) μg/L
CTX (ng/L)
Insulinopenic259.4 (IQR 163.4, 347.7)
Classical150.4 (IQR 103.5, 265.1)
Hyperinsulinemic163.3 (IQR 98.9, 273.1)
Osteocalcin (μg/L)
Insulinopenic18.0 (IQR 14.4, 25.2)
Classical13.1 (IQR 10.0, 17.6)
Hyperinsulinemic15.7 (IQR 10.2, 20.8)
- Insulinopenic vs Classical: all P < .01 — P1NP, CTX and osteocalcin higher with Insulinopenic
- Insulinopenic vs Hyperinsulinemic: all P < .01 — P1NP, CTX and osteocalcin higher with Insulinopenic
Observational data: associations, not effects.
Further findings
BTM differences adjusted for age, sex, WHR or FPG
- Differences persisted after adjustment
- P < 0.01
Original publication
Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes. J Clin Endocrinol Metab. Published 31 January 2023. doi:10.
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