Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition
Main finding · T2D incidenceResult — go to the resultIncidence rate ratio 0.60 95% CI 0.48–0.75Authors' conclusion
A lower birthweight was associated with increased risk of developing type 2 diabetes independent of adult BMI and genetic risk of type 2 diabetes and birthweight.
Study context
- Population
- Adults aged 30–60 years in the Danish Inter99 cohort (1999–2001), with birthweight from original birth records (1939–1971), without diabetes at baseline492 incident T2D cases
- Participants
- 4,590 adults
- Exposure
- Birthweight and T2D incidence
- Outcome
- Age-specific incidence rate of T2D
- Follow-up
- Mean 19 years
Methodological detailspopulation-based, birth records linked to individual-level data, Poisson regression
- Population-based
- Birth records linked to individual-level data
- Poisson regression
Main finding
T2D incidence
Incidence rate ratio
0.60
95% CI 0.48–0.75
Per 1 kg increase in birthweight
incidence rate ratio 0.60 (95% CI 0.48–0.75)
Per 1 kg increase in birthweight, as printed
As reported in the abstract
Observational data: associations, not effects.
Original publication
Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition. Diabetologia. Published 12 June 2023. doi:10.
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