Longitudinal Continuous Glucose Monitoring Study in Young Children With Presymptomatic Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) At-Risk Cohort Study
Authors' conclusion
Further research is needed to inform interpretation of CGM-derived metrics in young children with presymptomatic type 1 diabetes.
Study context
- Population
- Young children with presymptomatic T1D (persistent multiple islet autoimmunity) in the Australian ENDIA at-risk cohort, 2021–2024; median age at first assessment 4.5 [3.5, 6.0] years178 continuous glucose monitoring (CGM) assessments
- Participants
- 36 children
- Outcome
- Within-person variability of serial CGM metrics
Methodological detailslongitudinal, blinded CGM assessments every 3-6 months
- Longitudinal
- Blinded CGM assessments every 3-6 months
Main finding
As reported in the abstract
Intraclass correlation coefficient, % CGM time >7.8 mmol/L (140 mg/dL)
0.30
Observational data: associations, not effects.
Further findings
CGM assessments per child and duration
- Median assessments per child (Q1, Q3)
- 5.5 (2.0, 7.0)
- Median duration per assessment, days (Q1, Q3)
- 11 (9, 15)
Original publication
Longitudinal Continuous Glucose Monitoring Study in Young Children With Presymptomatic Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) At-Risk Cohort Study. Diabetes Care. Published 19 August 2025. doi:10.
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