Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information
Authors' conclusion
This comprehensive profile provides the context for understanding ENDIA's scope, methodology, unique strengths and limitations. Now fully recruited, ENDIA will provide unique insights into the roles of early-life factors in the development of islet autoimmunity and T1D in the Australian environment.
Study context
- Population
- Unborn children or infants aged <6 months with a first-degree relative with T1D, Australia1,214 mothers
- Participants
- 1,473 children1,453 pregnancies
- Exposure
- Mothers with T1D vs mothers without T1D
- Outcome
- Persistent islet autoimmunity
- Follow-up
- Followed until T1D diagnosis or 10 years of age
Methodological detailscohort profile, longitudinal, pregnancy to childhood, ongoing
- Cohort profile
- Longitudinal
- Pregnancy to childhood
- Ongoing
Main finding
As reported in the abstract
Cohort characteristics · birth
Enrolled during pregnancy
80%
T1D proband: maternal
62%
T1D proband: paternal
28%
T1D proband: sibling
11%
Observational data: associations, not effects.
Further findings
Maternal and neonatal outcomes by maternal T1D
- Mothers with T1D had higher rates of pregnancy complications and perinatal intervention, and larger babies of shorter gestation
Parent demographics vs Australian population
- Comparable for age, parity and obesity
- More ENDIA parents Australian born, living in a major city, with higher socioeconomic advantage and education
Original publication
Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information. BMJ Open Diabetes Res Care. Published 16 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →