Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes
Authors' conclusion
CGM is feasible and well tolerated in very young children at risk of T1D. Very young PM Ab+ children have increased SDSGL, CEV, and percentage of time >7.8 mmol/L, consistent with prior studies involving older participants.
Study context
- Population
- Very young children in the Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study (birth to age 10 years); mean (SD) age 4.4 (1.8) years PM Ab+ and 4.7 (1.9) years Ab-age-matched controls
- Participants
- 31 vs 24
- Comparison
- PM Ab+ vs Ab- children
- PM Ab+n = 31
- Ab-n = 24reference
- Outcome
- CGM metrics
Methodological detailsage-matched controls, nested in ENDIA longitudinal birth cohort, continuous glucose monitoring (CGM) assessment January 2021–June 2023 alongside standard clinical monitoring
- Age-matched controls
- Nested in ENDIA longitudinal birth cohort
- CGM assessment January 2021–June 2023 alongside standard clinical monitoring
Main finding
As reported in the abstract
- Higher glucose SD (SDSGL) in PM Ab+ vs Ab-: median (Q1, Q3) 1.1 (0.9, 1.3) vs 0.9 (0.8, 1.0) mmol/L
- P < 0.001
- Higher CV (coefficient of variation (CEV)) in PM Ab+ vs Ab-: 17.3% (16.0, 20.9) vs 14.7% (12.9, 16.6)
- P < 0.001
- Greater % time >7.8 mmol/L in PM Ab+ vs Ab-: median (Q1, Q3) 8.0% (4.4, 13.0) vs 3.3% (1.4, 5.3)
- P = 0.005
- Mean sensor glucose (SGL) did not differ significantly between groups
- P = 0.10
Observational data: associations, not effects.
Further findings
CGM feasibility
- Eligible PM Ab+ children consenting to CGM wear
- 86%
- Sensor wear period, median (Q1, Q3)
- 12.5 (9.0, 15.0) days
Original publication
Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes. Diabetes Care. Published 30 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →