Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study
Authors' conclusion
Although bone loss occurred before menopause, the loss accelerated in the early perimenopausal transition (45-50 years of age).
Study context
- Population
- Women aged 40–59 in the population-based Vietnam Osteoporosis Study; Bone mineral density (BMD) at femoral neck (FN), lumbar spine (LS) and whole body by DXA, two measurements ≈2 years apart
- Participants
- 1,062 women
- Outcome
- Rate of BMD change during the menopausal transition
Methodological detailspopulation-based, multivariable linear regression
- Population-based
- Multivariable linear regression
Main finding
As reported in the abstract
Rate of BMD change by age phase
- FN: slight decline before age 45-49 (average loss, %/year)
- 0.51
- FN: substantial decline between ages 49 and 54 (average loss, %/year)
- 1.39
- FN: slowed between ages 54 and 59 (average loss, %/year)
- 0.31
- LS: slight decline among women aged 45-49 (%/year)
- - 0.56
- LS: significant decline between ages 50 and 54 (%/year)
- - 1.33
- LS: slowed after age 55 (%/year)
- - 0.31
Observational data: associations, not effects.
Further findings
Association of BMD change with changes in lean mass or fat mass
- Changes in BMD not significantly associated with changes in lean mass or fat mass
Original publication
Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study. Osteoporos Int. Published 27 April 2023. doi:10.
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