Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest
Authors' conclusion
A long-term increase in ΔFBG can be associated with increased risk of SCA in people with DM. However, a long-term decrease in ΔFBG was not associated with reduced risk of SCA. Actions to prevent increase in FBG can have significant effects on public health in terms of SCA prevention.
Study context
- Population
- People with sequential nationwide health screening in 2009 and 2011analysed
- Participants
- 2,801,153 people
- Exposure
- Categories of long-term change in fasting blood glucose (FBG) vs euglycemic group
- Outcome
- Sudden cardiac arrest (SCA)
- Follow-up
- Mean 6.33 years
Methodological detailssequential nationwide health screening data (2009 and 2011)
- Sequential nationwide health screening data (2009 and 2011)
Main finding
As reported in the abstract
SCA risk
Each group vs euglycemicAdjusted hazard ratio (95% CI)P value
20 ≤ ΔFBG < 4025% increased risk
1.25(1.16–1.35)
P < 0.00140 ≤ ΔFBG < 10066% increased risk
1.66(1.49–1.86)
P < 0.001ΔFBG ≥ 1002.9-fold increased risk
2.85(2.37–3.44)
P < 0.001ΔFBG < −40
1.11(0.98–1.27)
P = 0.113- 40 ≤ ∆FBG < - 20
1.12(1.03–1.22)
P = 0.009Observational data: associations, not effects.
Further findings
Sudden cardiac arrest (SCA) by subgroup (diabetes mellitus (DM) status, sex, age, blood pressure, HF)
- Association between ΔFBG and SCA maintained in people with DM but not in people without DM
- Sex, age, blood pressure and presence of HF did not affect the association
Original publication
Long-term increase in fasting blood glucose is associated with increased risk of sudden cardiac arrest. Cardiovasc Diabetol. Published 20 February 2023. doi:10.
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