Long‐term glycemic exposure, glycemic control stability and incident calcific aortic valve disease: A prospective cohort study
Authors' conclusion
Type 2 diabetes, long-term elevated FBG and FBG change are associated with CAVD risk. Efforts to attain healthy glucose status may be an effective strategy to prevent CAVD.
Study context
- Population
- Participants of the Kailuan Study without CVD and free of calcific aortic valve disease (CAVD) at initial echocardiographic examination
- Participants
- 10,309 participants
- Exposure
- Long-term glycemic exposure and glycemic control stability vs incident CAVD
- Outcome
- Incident CAVD, ascertained through linkage with hospitals' electronic medical records
- Follow-up
- Median 4.62 years
Methodological detailsParticipants monitored biennially until 31 December 2023, Glucose changes calculated from three consecutive surveys prior to recruitment
- Participants monitored biennially until 31 December 2023
- Glucose changes calculated from three consecutive surveys prior to recruitment
Main finding
As reported in the abstract
Incident CAVD
- Developed CAVD
- 2062 patients
- HR for CAVD, T2D
- 1.42 (95% CI, 1.29-1.57)
- HR for CAVD, time weighted average (TWA) fasting blood glucose (FBG) level
- 1.20 (95% CI, 1.01-1.44)
- HR for CAVD, cumulative FBG level
- 1.37 (95% CI, 1.14-1.65)
- HR for CAVD, FBG time in target range (TTR)
- 0.72 (95% CI, 0.60-0.86)
Observational data: associations, not effects.
Original publication
Long‐term glycemic exposure, glycemic control stability and incident calcific aortic valve disease: A prospective cohort study. Diabetes Obes Metab. Published 19 November 2025. doi:10.
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