Lipoprotein(a) as a cardiovascular risk factor among patients with and without diabetes Mellitus: the Mass General Brigham Lp(a) Registry
Authors' conclusion
Elevated Lp(a) constitutes an independent and incremental risk factor for CAD outcomes in patients with and without DM.
Study context
- Population
- Patients ≥18 years with Lp(a) measured 2000–2019, MGB Lp(a) Registry; excluding severe kidney dysfunction, malignant neoplasms and prior atherosclerotic cardiovascular disease (ASCVD); median age 54, 45% women, 12% diabetes mellitus (DM)
- Participants
- 6,238 patients
- Exposure
- Elevated Lp vs not, in patients with and without DM
- Outcome
- Cardiovascular death or myocardial infarction (MI)
- Follow-up
- Median 12.9 years
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Annual event rate of CV death or MI
DM and Lp(a) > 90th% vs DM and Lp(a) < 90th%
Estimate (95% CI)P value
Hazard ratioadjusted for confounders
2.66(1.55–4.58)
P < 0.001No-DM and Lp(a) > 90th% vs No-DM and Lp(a) < 90th%
Estimate (95% CI)P value
Hazard ratioadjusted for confounders
2.01(1.48–2.74)
P < 0.001- Difference in annual event rates across the four groups
- P < 0.001
Observational data: associations, not effects.
Original publication
Lipoprotein(a) as a cardiovascular risk factor among patients with and without diabetes Mellitus: the Mass General Brigham Lp(a) Registry. Cardiovasc Diabetol. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →