The causal relationship between plasma protein‐to‐protein ratios and type 2 diabetes and its complications: Proteomics mendelian randomization study
Authors' conclusion
The outcomes of our investigation unveiled correlations between 23 plasma protein-to-protein ratios and type 2 diabetes, with eight of these ratios entwined with complications of type 2 diabetes. These discoveries offer novel perspectives on the diagnosis and management of type 2 diabetes and its associated complications.
Study context
- Population
- Genetic data from several large, publicly accessible genome-wide association studies; 2821 plasma protein-to-protein ratios
- Outcome
- Causal associations of plasma protein-to-protein ratios with T2D and its complications
Methodological detailstwo-sample, two-step, reverse Mendelian randomization (MR), sensitivity analyses
- Two-sample
- Two-step
- Reverse MR
- Sensitivity analyses
Main finding
As reported in the abstract
T2D
Protein-to-protein ratios causally associated with T2D across both sample cohorts (inverse-variance weighted)
23
Risk of T2D per 1 SD increase, CNTN3/NCSS1 ratio
0.93
95% CI 0.87, 1.00
Risk of T2D per 1 SD increase, DBNL/NCK2 ratio
1.13
1.06, 1.22
Further findings
T2D complications
- Protein-to-protein ratios associated with ≥1 T2D complication
- 8
Robustness
- Diverse sensitivity analyses corroborated the robustness of these observations
Original publication
The causal relationship between plasma protein‐to‐protein ratios and type 2 diabetes and its complications: Proteomics mendelian randomization study. Diabetes Obes Metab. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →