Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes
Authors' conclusion
We revealed a significant disruption of lipid metabolism associated with SCA in subjects with T2D, and a larger SCA-associated disruption in former/current smokers with T2D and individuals with T2D who do not undergo lipid-lowering treatment.
Study context
- Population
- Subjects with T1D, T2D and without diabetes; serum lipidomic profile (UHPLC-ESI-MS/MS) and carotid US for subclinical carotid atherosclerosis (SCA)
- Participants
- 513 subjects
- Exposure
- T1D vs T2D vs controls without diabetes
- T1Dn = 151
- T2Dn = 155
- Controlsn = 207reference
- Outcome
- Association between serum lipidomic features and presence and burden of SCA
Main finding
As reported in the abstract
Lipid species associated with SCA
- Unique lipid species associated with SCA in T2D, former/current smokers with T2D, and T2D without dyslipidaemia
- 27
- Phosphatidylcholine species up-regulated
- 10
- Phosphatidylcholines containing polyunsaturated fatty acids down-regulated
- 4
- Diacylglycerol down-regulated
- 1
- Diacylglycerols positively associated with SCA in T2D without dyslipidaemia
- 3
Observational data: associations, not effects.
Further findings
Prevalence of SCA
Original publication
Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes. Cardiovasc Diabetol. Published 2 April 2025. doi:10.
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