Link between triglyceride-glucose-body mass index and future stroke risk in middle-aged and elderly chinese: a nationwide prospective cohort study
Authors' conclusion
In the middle-aged and elderly Chinese population, elevated TyG-BMI was significantly and positively associated with stroke risk. In addition, there was also a specific non-linear association between TyG-BMI and stroke (inflection point 174.63). Further reduction of TyG-BMI below 174.63 through lifestyle changes and dietary control can significantly reduce the risk of stroke.
Study context
- Population
- Middle-aged and elderly Chinese individuals, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 8,698 participants
- Exposure
- Higher vs lower triglyceride glucose-body mass index (TyG-BMI)
- Outcome
- Incident stroke
Methodological detailsnationwide, CHARLS waves 2011, 2013, 2015, 2018, multistage probability sampling
- Nationwide
- CHARLS waves 2011, 2013, 2015, 2018
- Multistage probability sampling
Main finding
As reported in the abstract
HR per 10-unit increase in TyG-BMI (multivariate Cox; 4.9% higher risk), 95% CI 1.029-1.069
1.049
Observational data: associations, not effects.
Further findings
Non-linear association: stroke risk per 10-unit increase in TyG-BMI either side of inflection point 174.63
- TyG-BMI <174.63: HR (14.4% rise), 95% CI 1.044-1.253
- 1.144
- TyG-BMI >174.63: HR (3.8% increase), 95% CI 1.016-1.061
- 1.038
- Smooth curve fitting
Original publication
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