Prognostic effect of stress hyperglycemia ratio on patients with severe aortic stenosis receiving transcatheter aortic valve replacement: a prospective cohort study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.12 95% CI 1.04–1.21Authors' conclusion
Our study indicates linear relationships of SHR with the risk of all-cause mortality, cardiovascular mortality or readmission for heart failure, and MACE in patients with severe aortic stenosis receiving TAVR after a median follow-up of 3.9 years. Patients with an SHR exceeding 0.944 had a poorer prognosis compared to those with lower SHR values.
Study context
- Population
- Patients with severe native aortic stenosis undergoing transcatheter aortic valve replacement (TAVR)
- Participants
- 582 patients
- Exposure
- Stress hyperglycemia ratio (SHR)
- Outcome
- All-cause mortality
- Follow-up
- Median 3.9 years
Methodological detailsconsecutive enrolment
- Consecutive enrolment
Main finding
As reported in the abstract
Adjusted hazard ratio
1.12
95% CI 1.04–1.21
SHR per 0.1 unit increase
aHR 1.12 (95% CI 1.04–1.21)
Per 0.1 unit increase, as printed
- All-cause mortality events
- 130 (22.3%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| Cardiovascular mortality or readmission for HF | 1.12 (1.02–1.22) | |
| MACE (CV mortality, non-fatal MI, non-fatal stroke) | 1.12 (1.01–1.23) | |
| 0.512Adjusted hazard ratio (log scale) |
All-cause mortality by DM subgroup
- Significant interaction of SHR with DM (p for interaction: 0.042)
All endpoints by SHR cutoff 0.944 (Kaplan-Meier)
- Significant differences in incidence of all endpoints between the two groups (all log-rank test: p < 0.05)
Original publication
Prognostic effect of stress hyperglycemia ratio on patients with severe aortic stenosis receiving transcatheter aortic valve replacement: a prospective cohort study. Cardiovasc Diabetol. Published 16 February 2024. doi:10.
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