The effectiveness of sodium-glucose co-transporter 2 inhibitors on cardiorenal outcomes: an updated systematic review and meta-analysis
Authors' conclusion
This updated and comprehensive meta-analysis substantiates and strengthens the clinical recommendations of the CCS cardiorenal guidelines.
Study context
- Population
- Adults in placebo-controlled RCTs of SGLT2i and GLP-1 RA; mean age ranged from 59.9 to 68.4 years
- Participants
- 151,023 adults
- Comparison
- SGLT2i and GLP-1 RA vs standard care
- SGLT2in = 90,943
- GLP-1 RAn = 60,080
- Outcome
- Cardiorenal outcomes vs standard care
Methodological detailsplacebo-controlled trials, updated search, GRADE certainty assessment, indirect comparison, Search updated from September 2021 to April 2023; three new trials and additional results from an updated existing trial on SGLT2i included
- Placebo-controlled trials
- Updated search
- GRADE certainty assessment
- Indirect comparison
- Search updated from September 2021 to April 2023; three new trials and additional results from an updated existing trial on SGLT2i included
Pooled result
As reported in the abstract
- Cardiovascular (CV) mortality reduction, SGLT2i & GLP-1 RA
- 14% & 13%
- Any-cause mortality reduction, SGLT2i & GLP-1 RA
- 12% & 12%
- Major adverse CV events (MACE) reduction, SGLT2i & GLP-1 RA
- 11% & 14%
- Heart failure (HF) hospitalization reduction, SGLT2i & GLP-1 RA
- 30% & 9%
- CV death or HF hospitalization reduction, SGLT2i & GLP-1 RA
- 23% & 11%
- Kidney composite outcome reduction, SGLT2i & GLP-1 RA
- 32% & 22%
Further pooled results
Cardiorenal outcomes in T2D
- Non-fatal stroke reduction, only with GLP-1 RA, in T2D
- 16%
- HF hospitalization reduction, only with SGLT2i, in T2D
- 30%
- Both classes demonstrated significant cardiorenal protection in T2D
Original publication
The effectiveness of sodium-glucose co-transporter 2 inhibitors on cardiorenal outcomes: an updated systematic review and meta-analysis. Cardiovasc Diabetol. Published 15 February 2024. doi:10.
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