The association between the atherogenic index of plasma (AIP) and undiagnosed diabetes in acute coronary syndrome (ACS) patients with different body mass indexes and low-density lipoprotein cholesterol (LDL-C) levels: findings from the CCC-ACS project
Main finding · Undiagnosed diabetesResult — go to the resultOdds ratio 1.533 CI 1.199–1.959Authors' conclusion
The AIP was significantly associated with the incidence of undiagnosed diabetes in ACS patients, especially in those with normal weight or an LDL-C level ≥ 1.8 mmol/L. A nonlinear relationship was found between the AIP and the incidence of undiagnosed diabetes, and this trend was consistent between male and female patients. The AIP may be a negative biomarker associated with undiagnosed diabetes and ranges from 0.176 to 0.738.
Study context
- Population
- ACS patients treated with coronary angiography at 240 hospitals, Improving Care for CVD in China-ACS Project, 2014–2019of 113,650 ACS patients
- Participants
- 11,221 patients
- Exposure
- AIP tertiles
- Outcome
- Undiagnosed diabetes
Methodological detailsmulticentre, registry-based (CCC-ACS project)
- Multicentre
- Registry-based (CCC-ACS project)
Main finding
As reported in the abstract
Odds ratio
1.533
CI 1.199–1.959
P < 0.001
Observational data: associations, not effects.
Further findings
Subgroups by body mass index (BMI) and LDL-C
- Association consistent in normal weight patients and LDL-C ≥ 1.8 mmol/L
- Overweight and obese: associated as continuous variable (adjusted for age, sex, BMI) but not as categorical variable
AUC for undiagnosed diabetes
- AIP AUC
- 0.601 (0.581-0.622; p < 0.001)
- Triglyceride (TG) AUC
- 0.624 (0.603-0.645; p < 0.001)
- HDL-C AUC
- 0.493 (0.472-0.514; p = 0.524)
Nonlinearity of AIP–undiagnosed diabetes association
- AIP may be a negative biomarker associated with undiagnosed diabetes, range
- 0.176 to 0.738
- Nonlinear association (p for nonlinearity < 0.001), consistent between males and females
Original publication
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