Association of the triglyceride–glucose index with coronary artery disease complexity in patients with acute coronary syndrome
Authors' conclusion
A higher TyG index was associated with the presence of a higher coronary anatomical complexity (SYNTAX score > 22) in ACS patients, irrespective of diabetes mellitus status. The TyG index might serve as a noninvasive predictor of CAD complexity in ACS patients and could potentially influence the management and therapeutic approach.
Study context
- Population
- Patients presenting with acute coronary syndrome (ACS) undergoing coronary angiography
- Participants
- 1,007 patients
- Exposure
- Triglyceride-glucose (TyG) index tertiles T2 and T3 vs T1
- Outcome
- Mid/high SYNTAX score (SYNTAX score > 22)
Main finding
As reported in the abstract
Mid/high SYNTAX score (> 22)
Each group vs T1Odds ratio (95% CI)P value
T2
2.574(1.610–4.112)
P < 0.001T3
3.732(2.330–5.975)
P < 0.001- TyG index (continuous) as independent risk factor for mid/high SYNTAX score, adjusted OR
- 2.6452 (95% CI 1.9020-3.6786, P < 0.0001)
Observational data: associations, not effects.
Further findings
Dose-response between TyG index and complicated coronary artery disease (CAD) (SYNTAX score > 22)
- Dose-response relationship present; nonlinear P
- 0.200
Mid/high SYNTAX score by glycaemic status subgroup
- Risk in T2 and T3 significantly higher in normoglycemia, prediabetes and DM subgroups
Original publication
Association of the triglyceride–glucose index with coronary artery disease complexity in patients with acute coronary syndrome. Cardiovasc Diabetol. Published 12 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →