Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients without diabetes mellitus after coronary artery bypass grafting: a multicenter retrospective cohort study
Authors' conclusion
The TyG index may be an independent factor for predicting adverse cardiovascular events in nondiabetic patients after CABG.
Study context
- Population
- Patients without diabetes mellitus (DM) after coronary artery bypass grafting (CABG), 3 tertiary public hospitals, 2014–2018
- Participants
- 830 patients
- Exposure
- Higher vs lower triglyceride-glucose (TyG) index tertiles
- Outcome
- MACE
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Hazard ratio (95% CI)
TyG tertile 3
2.22(1.46–3.38)
Per SD increase in TyG index
1.38(1.18–1.62)
Per SD increase in TyG index, as printed
- Incrementally higher TyG index associated with increasingly higher cumulative incidence of MACE (log-rank test)
- P < 0.001
Observational data: associations, not effects.
Further findings
Incremental predictive value of adding TyG index to baseline model
- C-statistic increased from 0.656 to 0.680
- P < 0.001
- Continuous net reclassification improvement (NRI)
- 0.269 (0.100-0.438), p = 0.002 (95% CI)
- Integrated discrimination improvement (IDI)
- 0.014 (0.003-0.025), p = 0.014 (95% CI)
Original publication
Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients without diabetes mellitus after coronary artery bypass grafting: a multicenter retrospective cohort study. Cardiovasc Diabetol. Published 30 August 2023. doi:10.
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