The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study
Main finding · MACEResult — go to the resultHazard ratio 2.45 95% CI 1.23–4.95Authors' conclusion
The TyG index constitutes an autonomous MACE predictor specifically within the distinctive cohort of patients manifesting both T2DM and HUA. This study is the first to validate the TyG > 8.40 threshold in T2DM patients with HUA and identify a synergistic interaction between serum uric acid (SUA) and TyG, providing a novel stratification tool for managing dual metabolic disorders.
Study context
- Population
- Patients with both T2DM and hyperuricemia (HUA), Chaohu Hospital (Anhui Medical University), 2019–2024
- Participants
- 628 patients74 major adverse cardiovascular events (MACEs)
- Exposure
- Highest vs lowest triglyceride-glucose (TyG) index tertile
- Outcome
- MACE
- Follow-up
- 38.00 ± 8.78 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
2.45
95% CI 1.23–4.95
Highest tertilevs Lowest tertile
HR 2.45 (95% CI 1.23–4.95)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACE per SD increase in TyG index above threshold TyG > 8.40 | 1.66 (1.36–2.36) | P = 0.014 | |
| 0.512Hazard ratio (log scale) |
Incremental predictive value of TyG added to traditional risk models
- C statistic increase
- 0.64 → 0.67, P = 0.029
- Net reclassification improvement (NRI)
- 0.14, P < 0.05
- Integrated discrimination improvement (IDI)
- 0.02, P < 0.05
Original publication
The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study. Cardiovasc Diabetol. Published 21 May 2025. doi:10.
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