Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution
Authors' conclusion
This study demonstrated life stage-specific heterogeneity in the effects of excess adiposity on hypertension, with individuals in childhood and early life conferring stronger influences. These results underscore the importance of considering age-specific approaches to weight management for hypertension prevention and control.
Study context
- Population
- Chinese participants aged 3 to 80 years, China Health and Nutrition Survey
- Participants
- 24,104 participants
- Exposure
- Excess adiposity at baseline and adiposity status transition vs normal adiposity, by life stage
- Outcome
- Hypertension incidence and resolution
Methodological detailsgeneralized linear mixed-effects model
- Generalized linear mixed-effects model
Main finding
As reported in the abstract
Hypertension incidence by life stage
- High baseline body mass index (BMI), early adulthood (strongest), OR
- 2.29 (2.14-2.45) (95% CI)
- High baseline waist circumference (WC), childhood (strongest), OR
- 3.14 (1.75-5.20) (95% CI)
- Normal to high BMI, 3-17 y (strongest; increased risk across all age groups), OR
- 2.08 (1.42-2.96) (95% CI)
- Normal to high WC, 3-17 y (strongest), OR
- 3.41 (2.26-4.97) (95% CI)
- High to normal BMI, 3-17 y (strongest), OR
- 4.73 (0.50-57.5) (95% CI)
- High to normal WC, 18-40 y (strongest), OR
- 2.52 (1.48-4.44) (95% CI)
Observational data: associations, not effects.
Original publication
Life stage-specific heterogeneity in the effects of adiposity transition on hypertension incidence and resolution. Int J Obes (Lond). Published 1 April 2026. doi:10.
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