Life-long body mass index trajectories and cardiometabolic biomarkers-the Danish diet, cancer, and health-next generations cohort
Authors' conclusion
Both those with constant high BMI and steeply increased BMI trajectories from age 20 had more unfavorable cardiometabolic profiles compared to those maintaining lower BMI throughout adulthood.
Study context
- Population
- Participants of the Danish Diet, Cancer and Health - Next Generations cohort; recalled weight history per decade, body mass index (BMI) trajectories from age 20 to current age
- Participants
- 30,581 participants
- Exposure
- BMI trajectory groups vs Stable low BMI
- Stable low BMIn = 9,753reference
- Gradual BMI increasen = 13,780
- Early high BMIn = 771
- Steeper BMI increasen = 6,277
- Outcome
- Cardiometabolic biomarkers (HbA1c, total cholesterol, TG, HDL, LDL, C-reactive protein, creatinine) by BMI trajectory
Methodological detailslatent class growth models, adjusted for age, sex and smoking status
- Latent class growth models
- Adjusted for age, sex and smoking status
Main finding
As reported in the abstract
Triglycerides
β
0.36 mmol/L
95% CI 0.34–0.38
Steeper BMI increase
β
0.30 mmol/L
95% CI 0.26–0.34
Early high BMI
β
0.12 mmol/L
95% CI 0.11–0.13
Gradual BMI increase
Observational data: associations, not effects.
Original publication
Life-long body mass index trajectories and cardiometabolic biomarkers-the Danish diet, cancer, and health-next generations cohort. Int J Obes (Lond). Published 22 August 2025. doi:10.
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