Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans
Authors' conclusion
This is the first study demonstrating that a biologically active dose of kisspeptin to men and women does not affect behavioral, biochemical, or physiological measures of anxiety. Given that animal studies have yielded contradictory results, this provides key clinical data and reassurance that kisspeptin does not induce anxiety in humans and so informs the current development of kisspeptin-based therapeutics for common reproductive and psychosexual disorders.
Study context
- Population
- Men and women (63 male, 32 female); mean age ± SEM 30.9 ± 0.9 y, BMI 24.0 ± 0.4crossover
- Participants
- 95 men
- Comparison
- IV kisspeptin-54 infusion vs rate-matched placebo
Methodological detailsdouble-blind, placebo-controlled, crossover
- Double-blind
- Placebo-controlled
- Crossover
Primary result
As reported in the abstract
State anxiety (psychometric questionnaire) · end of infusion
- State anxiety was not significantly altered by kisspeptin vs placebo
- Kisspeptin vs Placebo: P = 0.13
Further findings
| Outcome | P value |
|---|---|
| Serum LHRobustly increased with kisspeptin | P < 0.001 |
| Circulating cortisolNo significant effect | P = 0.73 |
| Systolic blood pressureNo significant effect | P = 0.74 |
| Diastolic blood pressureNo significant effect | P = 0.90 |
| Heart rateNo significant effect | P = 0.52 |
Original publication
Kisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans. J Clin Endocrinol Metab. Published 26 February 2025. doi:10.
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