Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome
Authors' conclusion
Hypogonadism in men with CS is widely prevalent but reversible in approximately 75% of patients 1 year after surgical cure and appears to be mediated through suppression of hypothalamic GnRH secretion, and modulated by thyroid hormones.
Study context
- Population
- Men with adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome (CS) undergoing curative surgery
- Participants
- 8 vs 44
- Comparison
- Before vs after curative surgery for CS
- C1n = 8
- C2n = 44
- Primary endpoint
- Frequency of male hypogonadism before and after curative surgery (C2); LH, FSH, LH pulse frequency and LH response to GnRH (C1)
Methodological detailssingle clinical research center, longitudinal
- Single clinical research center
- Longitudinal
Primary result
As reported in the abstract
Hypogonadism frequency (C2)
Baseline hypogonadism, C2
82%
Baseline total T, C2
205 ± 28 ng/dL
Persistent hypogonadism at 6 M post surgery, C2
51%
Persistent hypogonadism at 12 M post surgery, C2
26%
Further findings
Pulsatile LH and gonadotropin-releasing hormone (GnRH) response (C1) · after surgery
- Mean LH and LH pulse frequency increased after surgery
- P < 0.05
- No changes in LH pulse amplitude, mean FSH, or peak gonadotropin response to GnRH
Hormones after surgery (C2) · 6 and 12 M
- LH, total and free T, and SHBG increased at 6 and 12 M post surgery
Thyroid hormones (C2)
- Thyroid hormone levels varied inversely with urine free cortisol (UFC) and cortisol
Original publication
Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome. J Clin Endocrinol Metab. Published 17 July 2024. doi:10.
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