Joint Trajectories of Physical Activity and Depressive Symptoms and Incident Cardiometabolic Multimorbidity: A Multi‐Cohort Study
Authors' conclusion
Joint trajectories of physical activity and depressive symptoms were associated with incident CMM across four international ageing cohorts.
Study context
- Population
- Adults aged ≥45 years in four population-based ageing cohorts (ELSA, HRS, SHARE, CHARLS)
- Participants
- 29,523 adults4 cohorts
- Exposure
- Low physical activity and high depressive symptoms joint trajectory vs cohort-specific reference trajectory
- Outcome
- Incident cardiometabolic multimorbidity (CMM): coexistence of ≥2 of hypertension, diabetes, heart disease and stroke
Methodological detailsharmonized data from four population-based ageing cohorts (ELSA, HRS, SHARE, CHARLS), KmL3D joint trajectory modelling, Cox proportional hazards models
- Harmonized data from four population-based ageing cohorts (ELSA, HRS, SHARE, CHARLS)
- KmL3D joint trajectory modelling
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident CMM
Lower physical activity and high depressive symptoms vs Reference trajectoryHazard ratio (95% CI)
ELSA
2.15(1.67–2.77)
HRS
1.46(1.22–1.74)
SHARE
1.85(1.69–2.03)
CHARLS
2.28(1.52–3.44)
Observational data: associations, not effects.
Further findings
- Findings were directionally consistent across sensitivity analyses
Original publication
Joint Trajectories of Physical Activity and Depressive Symptoms and Incident Cardiometabolic Multimorbidity: A Multi‐Cohort Study. Diabetes Obes Metab. Published 22 July 2026. doi:10.
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