Diabetes overtreatment and flags for deprescribing glucose‐lowering treatment in geriatric inpatients with type 2 diabetes: Prognostic insights from a longitudinal cohort
Authors' conclusion
The cumulative burden of deprescribing flags provided complementary information beyond the current overtreatment definition.
Study context
- Population
- Geriatric inpatients aged ≥75 years with T2D on glucose-lowering treatment (GLT), hospitalised 2008–2015
- Participants
- 447 inpatients
- Exposure
- Overtreated vs not overtreated; number of deprescribing flags
- Outcome
- Survival (mortality)
- Follow-up
- five-year
Methodological detailssingle-centre, longitudinal
- Single-centre
- Longitudinal
Main finding
As reported in the abstract
Mortality · five-year follow-up
Hazard ratio (95% CI)
Overtreatment
1.29(1.04–1.58)
Deprescribing flags (per additional flag)per additional flag
1.20(1.11–1.29)
Per additional flag, as printed
Observational data: associations, not effects.
Further findings
Prevalence of health status, overtreatment and deprescribing flags
- Poor health status
- 89%
- Overtreated
- 55.2%
- ≥1 deprescribing flag
- 99.5%
- Not overtreated among patients with ≥1 deprescribing flag
- 44%
Overall survival after hospitalisation · five-year follow-up
- Median survival time
- 1.83 years [IQR, 1.56-2.09]
- Five-year survival
- 18% [95%CI, 15%-22%]
Five-year survival in patients with ≥4 deprescribing flags and overtreated
- Worst survival outcomes; five-year survival rate
- 10%
Original publication
Diabetes overtreatment and flags for deprescribing glucose‐lowering treatment in geriatric inpatients with type 2 diabetes: Prognostic insights from a longitudinal cohort. Diabet Med. Published 22 July 2026. doi:10.
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