Efficacy of Dapagliflozin by Baseline Diabetes Medications: A Prespecified Analysis From the DAPA-CKD Study
Authors' conclusion
Dapagliflozin reduced kidney and cardiovascular events in patients with type 2 diabetes and CKD across baseline GLT class or classes in combination.
Study context
- Population
- Adults with estimated glomerular filtration rate (eGFR) 25–75 mL/min/1.73 m² and urinary albumin-to-creatinine ratio 200–5,000 mg/g; analysis in T2D and chronic kidney disease (CKD) by baseline glucose-lowering therapy (GLT) class or number of GLTs2,906 with T2D
- Participants
- 4,304 adults
- Comparison
- Dapagliflozin 10 mg vs placebo once daily, by baseline glucose-lowering therapy (GLT)
- Primary endpoint
- Composite of:
- ≥50% eGFR decline
- End-stage kidney disease
- Kidney or cardiovascular death
Methodological detailsprespecified subgroup analysis, placebo-controlled
- Prespecified subgroup analysis
- Placebo-controlled
Primary result
As reported in the abstract
Primary composite outcome:
- By baseline GLT class
- Number of GLTs
- Effects of dapagliflozin on the primary composite outcome consistent across GLT classes and number of GLTs
- Dapagliflozin vs Placebo: all interaction P > 0.08
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Initiation of insulin therapy during follow-up | 0.72 (0.54–0.96) | P = 0.025 | |
| 0.512Hazard ratio (log scale) |
Secondary end points (kidney composite, cardiovascular composite, all-cause mortality) by GLT class or number
- Consistent benefit of dapagliflozin vs placebo regardless of background GLT class or number of GLTs
Rate of eGFR decline by GLT class or number
- Consistent effect of dapagliflozin regardless of background GLT
Safety
- Safety end points consistent regardless of background GLT class or number of GLTs
Original publication
Efficacy of Dapagliflozin by Baseline Diabetes Medications: A Prespecified Analysis From the DAPA-CKD Study. Diabetes Care. Published 20 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →