Association of circadian rest-activity rhythms with cardiovascular disease and mortality in type 2 diabetes
Authors' conclusion
Objectively determined CRAR disturbances may increase the risk of cardiovascular diseases and mortality among people with type 2 diabetes.
Study context
- Population
- Participants with baseline T2D from UK Biobank (mean age 65.21 years, 39.78% female; mean HbA1c 50.02 mmol/mol)
- Participants
- 3,147 participants
- Exposure
- Lowest vs highest quartile of circadian rest-activity rhythm (CRAR) parameters
- Outcome
- CVD and mortality
Methodological detailsUK Biobank, accelerometer-derived CRAR parameters, Cox proportional hazards models
- UK Biobank
- Accelerometer-derived CRAR parameters
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident CVD
Q1 vs Q4Estimate (95% CI)
IS
HR (IS) 1.40(1.04–1.88)
RA
HR (RA) 2.45(1.73–3.49)
Observational data: associations, not effects.
Further findings
- High intradaily variability (IV) and low relative amplitude (RA) were associated with all-cause and cardiovascular mortality
Original publication
Association of circadian rest-activity rhythms with cardiovascular disease and mortality in type 2 diabetes. Diabetes Res Clin Pract. Published 20 January 2023. doi:10.
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