The Impact of Acute Nutritional Interventions on the Plasma Proteome
Authors' conclusion
Our study identifies APOC1 as a dominant nutritional responder in humans and highlights the interdependency of acute nutritional response proteins and the endocrine system.
Study context
- Population
- Healthy young men (caloric restriction); Ely epidemiological study participants (glucose challenge); random individuals from Generation Scotland
- Participants
- 10 / 200 / 200
- Comparison
- Plasma proteome before vs after acute nutritional interventions
- Caloric restrictionn = 10
- Elyn = 200
- Generation Scotlandn = 200
- Outcome
- Plasma proteome response to acute nutritional interventions
Methodological detailshigh-throughput mass spectrometry, three cohorts
- High-throughput mass spectrometry
- Three cohorts
Main finding
As reported in the abstract
- Both caloric restriction and the glucose challenge substantially impacted the plasma proteome
- Proteins responded across individuals or in an individual-specific manner
- Nutrient-responsive plasma proteins correlated with changes in the metabolome and with endocrine parameters
- Apolipoprotein C1 (APOC1) was affected by caloric restriction, dominated the response to glucose consumption and differed in abundance between individuals with and without T2D
Original publication
The Impact of Acute Nutritional Interventions on the Plasma Proteome. J Clin Endocrinol Metab. Published 20 January 2023. doi:10.
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