The rest‐activity rhythm, genetic susceptibility and risk of type 2 diabetes: A prospective study in UK Biobank
Authors' conclusion
The unbalanced RAR are associated with a greater risk of T2D, which are independent of known risk factors of T2D.
Study context
- Population
- Participants without diabetes in the UK Biobank cohort
- Participants
- 97,503 participants
- Exposure
- Lowest vs highest quartile of rest-activity rhythm (RAR) parameters; highest quartile of L5
- Outcome
- Incident T2D
Methodological detailsUK Biobank, wearable accelerometry, polygenic risk score
- UK Biobank
- Wearable accelerometry
- Polygenic risk score
Main finding
As reported in the abstract
T2D · 692 257 person-years follow-up
Hazard ratio (95% CI)
Lowest quartile of RAvs Highest quartile of RAadjusted
2.06(1.76–2.41)
Lowest quartile of M10vs Highest quartile of M10adjusted
1.33(1.19–1.49)
Highest quartile of L5vs Highest RA/M10 quartilehigher risk of T2D
1.78(1.55–2.24)
- Incident T2D cases documented
- 2434
Observational data: associations, not effects.
Further findings
Joint effect of high T2D-PRS with lowest quartile of relative amplitude (RA) or M10, or highest quartile of L5, on T2D
| HR (95% CI) | ||
|---|---|---|
| High T2D-PRS + lowest quartile of RA | 4.46 (3.36–6.42) | |
| High T2D-PRS + lowest quartile of M10 | 3.15 (2.29–4.32) | |
| High T2D-PRS + highest quartile of L5 | 3.09 (2.40–3.99) | |
| 0.10.31310Hazard ratio (log scale) |
Modification by T2D-PRS of RAR–T2D association
- No modification effects of T2D-PRS observed
- P > 0.05
Original publication
The rest‐activity rhythm, genetic susceptibility and risk of type 2 diabetes: A prospective study in UK Biobank. Diabetes Obes Metab. Published 1 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →