Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents
Main finding · DiabetesResult — go to the resultAdjusted hazard ratio 2.17 95% CI 1.17–4.04Authors' conclusion
Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.
Study context
- Population
- Adolescents (16–19 years) examined before military service, 1993–2015, Israel
- Participants
- 1,611,467 adolescents
- Exposure
- Isolated glucosuria vs no glucosuria in adolescence
- Glucosurian = 755
- Outcome
- Diabetes in adulthood (early-onset diabetes)
Methodological detailslinked with Israeli National Diabetes Registry, Cox models
- Linked with Israeli National Diabetes Registry
- Cox models
Main finding
Diabetes
Adjusted hazard ratio
2.17
95% CI 1.17–4.04
By group
Glucosuria
87.5 per 100,000 person-years
Nonglucosuric
43.3 per 100,000 person-years
Glucosuriavs Nonglucosuric
aHR 2.17 (95% CI 1.17–4.04)
As reported in the abstract
- Diabetes cases recorded during follow-up (all participants)
- 10,328
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline characteristics: males; BMI ≥ 85th percentile · adolescenceMales 75% vs. 57%; BMI ≥ 85th percentile 10.4% vs. 16.3% | all P < 0.001 |
Original publication
Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents. Diabetes Care. Published 26 February 2025. doi:10.
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