Islet autoantibody frequency in relatives of children with type 1 diabetes who have a type 2 diabetes diagnosis
Authors' conclusion
This study highlights the importance of measuring islet autoantibodies, including IAA, in relatives of people with type 1 diabetes to avoid misdiagnosis.
Study context
- Population
- Relatives of children with T1D who were later diagnosed with T2D; 64% men, mean age at sampling 41 years, mean age 54 years at diagnosis
- Participants
- 226 relatives
- Outcome
- Islet autoantibody positivity (≥1 autoantibody) in pre-diagnosis samples
- Follow-up
- More than a decade before diagnosis
Main finding
As reported in the abstract
Islet autoantibody-positive for at least one autoantibody
32
14%
Observational data: associations, not effects.
Further findings
GADA positivity by insulin treatment · GADA-positivity higher in insulin-treated
P < 0.001
Insulin treatment among autoantibody-positive relatives
- Treated with insulin (approximately half of autoantibody-positive)
- n = 15
IAA positivity among autoantibody-positive relatives
- IAA-positive
- 13/32 (41%)
Type 1 diabetes genetic risk score (GRS2)
- GRS2 increased in autoantibody-positive relatives
- P = 0.032
- No clear evidence for a difference in GRS2 according to treatment
- P = 0.072
Original publication
Islet autoantibody frequency in relatives of children with type 1 diabetes who have a type 2 diabetes diagnosis. Diabet Med. Published 27 June 2024. doi:10.
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