Associations between diabetes-related genetic risk scores and residual beta cell function in type 1 diabetes: the GUTDM1 study
Authors' conclusion
Diabetes-related GRS are associated with residual beta cell function in individuals with type 1 diabetes. These findings suggest some genetic contribution to preservation of beta cell function.
Study context
- Population
- Individuals with T1D; age 41.7 ± 14.9 years, duration of diabetes 16.0 years [IQR 6.0–29.0], HbA1c 55.6 ± 12.2 mmol/mol
- Participants
- 479 individuals
- Outcome
- Residual beta cell function (urinary C-peptide/creatinine ratio, UCPCR) and CGM metrics in relation to genetic risk scores (GRS)
Main finding
As reported in the abstract
Higher GRS-1: undetectable UCPCR, OR (95% CI 0.69, 0.89); attenuated after correction for disease duration
0.78
Higher GRS-2: undetectable UCPCR, OR (95% CI 0.75, 0.93); attenuated after correction for sex and age of onset
0.84
Higher GRS-C2: detectable UCPCR (≥0.01 nmol/mmol) after correction for sex and age of onset, OR
6.95
95% CI 1.19, 40.75
Observational data: associations, not effects.
Further findings
Association of GRS-T2D with CGM metrics
- Higher GRS-T2D: less time below range (TBR), OR for TBR<4%
- 1.41 (95% CI 1.01 to 1.96)
- Higher GRS-T2D: lower glucose CV, β
- −1.53 (95% CI −2.76, −0.29)
Original publication
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