Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity
Main finding · BMIResult — go to the resultDifference 1.5 kg/m² 95% CI 0.58–2.5Authors' conclusion
Lower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.
Study context
- Population
- Dominican and African American children from New York City (1998–2006); adiposity assessed at age 5, 7, 9 and 11 years
- Participants
- 336 participants
- Exposure
- Low vs middle vs high cord blood mitochondrial DNA copy number (mtDNAcn) tertiles
- Outcome
- Child BMI, BMI z score, fat mass index and body fat percentage
- Follow-up
- Age 5, 7, 9, and 11 years
Main finding
BMI · across childhood
Difference
1.5 kg/m²
95% CI 0.58–2.5
Low mtDNAcnvs Middle mtDNAcn
difference 1.5 kg/m² (95% CI 0.58–2.5)
As reported in the abstract
Observational data: associations, not effects.
Further findings
BMI z score, fat mass index, body fat percentage
- Results were similar to BMI
Adiposity trajectory class
- Low-mtDNAcn group had increased odds of being in an "increasing" or "high-stable" adiposity class
- Latent class growth models
Original publication
Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity. Obesity (Silver Spring). Published 7 March 2024. doi:10.
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