The association between patterns of weight change, diabetes status and glycaemia among adults with overweight and obesity
Authors' conclusion
Compared to those who did not lose weight, participants who maintained their weight loss had lower HbA1c levels after 1 year and 5 years, which highlights the importance of providing long-term support to prevent weight regain.
Study context
- Population
- Adults with overweight or obesity (BMI ≥28 kg/m²) from a weight management trial
- Participants
- 435 adults
- Exposure
- Weight change patterns vs no weight loss
- Outcome
- Incident non-diabetic hyperglycaemia (NDH) and HbA1c levels
- Follow-up
- 5 years
Methodological detailspooled data from a weight management trial
- Pooled data from a weight management trial
Main finding
As reported in the abstract
Incident NDH · between 1-year and 5-year follow-ups
Participants who developed non-diabetic hyperglycaemia (NDH)
77
Observational data: associations, not effects.
Further findings
| Outcome | Mean HbA1c difference (%) (95% CI) | |
|---|---|---|
| HbA1c · 1 yearMaintainersvs No weight loss | −0.15 (−0.22 to −0.10) | |
| HbA1c · 5 yearsMaintainersvs No weight loss | −0.15 (−0.23 to −0.06) | |
| −0.3−0.2−0.100.1Difference, % (linear scale) |
HbA1c · 5 years
- No difference in HbA1c between Regainers and No weight loss
Original publication
The association between patterns of weight change, diabetes status and glycaemia among adults with overweight and obesity. Diabetes Res Clin Pract. Published 6 March 2024. doi:10.
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