Intrapancreatic Fat Deposition and Metabolic Signatures Across Adiposity Phenotypes in Chinese Adults: A Computed Tomography Analysis
Authors' conclusion
IPFD was associated with an early metabolic signature, notably elevated TG, FFA, and TyG, independent of BMI and MASLD.
Study context
- Population
- Chinese adults with non-enhanced computed tomography (CT); mean age 63.8 ± 13.6 years, 44.4% male
- Participants
- 558 adults
- Exposure
- Lower vs higher P-S Difference
- Outcome
- Associations of IPFD (P-S Difference on non-enhanced CT; lower values = greater IPFD) with metabolic biomarkers
Methodological detailssingle-centre, multiple imputation, sequentially adjusted multivariable regression, restricted cubic splines, directed acyclic graph-informed mediation, stratified analyses
- Single-centre
- Multiple imputation
- Sequentially adjusted multivariable regression
- Restricted cubic splines
- Directed acyclic graph-informed mediation
- Stratified analyses
Main finding
As reported in the abstract
Associations of P-S Difference with metabolic biomarkers (fully adjusted model)
- Fasting plasma glucose (FPG): β (95% CI −0.0136 to 0.0000; p = 0.049); lower P-S Difference with higher FPG
- −0.0068
- Triglycerides (TG): β ([−0.0043 to −0.0002]; p = 0.028); lower P-S Difference with higher TG
- −0.0023
- Free fatty acids (FFA): β ([−0.0021 to −0.0003]; p = 0.012); lower P-S Difference with higher FFA
- −0.0012
- Triglyceride glucose (TyG) index: β ([−0.0046 to −0.0010]; p = 0.002); lower P-S Difference with higher TyG
- −0.0028
- High-density lipoprotein cholesterol (HDL-C): β ([0.0002 to 0.0024]; p = 0.025); lower P-S Difference with lower HDL-C
- 0.0013
Observational data: associations, not effects.
Further findings
Clinical diagnoses (hypertension, metabolic syndrome, T2D, coronary heart disease)
- Associations non-significant after adjustment
Mediation by body mass index (BMI) and MASLD
- BMI mediated associations
- ≤ 7.1%
- MASLD partially mediated TG (p = 0.017)
- 22.5%
- MASLD partially mediated TyG (p = 0.019)
- 15.7%
Original publication
Intrapancreatic Fat Deposition and Metabolic Signatures Across Adiposity Phenotypes in Chinese Adults: A Computed Tomography Analysis. Diabetes Obes Metab. Published 12 May 2026. doi:10.
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