Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study
An erratum to this article was published (Cardiovasc Diabetol, 23 Sep 2025 ↗)
Authors' conclusion
In this cohort of individuals with long-term type 1 diabetes I-FABP associated significantly with coronary artery stenosis, suggesting a potential role of gut mucosa damage in the process of atherosclerosis in type 1 diabetes.
Study context
- Population
- Individuals with long-term T1D and control subjects; established coronary heart disease (CHD) or computed tomography coronary angiography (CTCA) to assess coronary atherosclerosis102 T1D, 63 controls
- Exposure
- T1D with CHD or significant stenosis on CTCA vs T1D with normal arteries or non-significant stenosis
- Outcome
- I-FABP levels (T1D)
Methodological detailscontrolled
- Controlled
Main finding
As reported in the abstract
P = 0.003
- Intestinal fatty acid binding protein (I-FABP) associated with significant stenosis on CTCA (>50%) or established CHD, adjusted OR
- 2.32 (95% CI 1.09-4.95; p = 0.029)
Observational data: associations, not effects.
Further findings
- Correlation of I-FABP with total coronary plaque volume
- r = 0.22, p < 0.05
- Association after adjusting for age, sex, persistent albuminuria, eGFR, statin, DM duration, time-weighted HbA1c, LDL-C and systolic BP, OR
- 1.97 (95% CI 1.28-3.01; p = 0.002)
Original publication
Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study. Cardiovasc Diabetol. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →