Characterisation of islet antibody‐negative type 1 diabetes mellitus in Indian children
Authors' conclusion
The frequency of various islet-antibodies, in isolation and combination, differed considerably from studies among children of European descent with T1DM. Children with T1DM who were islet antibody-negative were indistinguishable from those who were antibody-positive.
Study context
- Population
- North Indian children aged 1–18 years, assessed within 2 weeks of T1D diagnosis; 12 with monogenic diabetes excluded12 monogenic excluded
- Participants
- 176 children
- Exposure
- Islet antibody-negative vs antibody-positive T1D
- Antibody-negativen = 24
- Outcome
- Frequency of antibody-negative T1D and comparison with antibody-positive T1D
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Islet antibody frequency · within 2 weeks of diagnosis
- GADA positive
- 124 (76%)
- IA-2A positive
- 60 (37%)
- ZnT8A positive
- 62 (38%)
- Negative for all antibodies
- 24 (15%)
- Single antibody (most frequently GADA)
- 68 (41%)
- All three antibodies
- 34 (21%)
Observational data: associations, not effects.
Further findings
Clinical features, HbA1c, C-peptide: antibody-negative vs antibody-positive · onset and 1 year (available in 62 children)
- Did not differ in clinical features, HbA1c or plasma C-peptide, at onset or after 1 year
Other organ-specific antibodies and high-risk HLA-DR and DQ alleles
- Frequencies similar in antibody-negative and antibody-positive
Single vs multiple islet antibodies
- Children with a single islet antibody did not differ from those with multiple antibodies
Original publication
Characterisation of islet antibody‐negative type 1 diabetes mellitus in Indian children. Diabet Med. Published 18 November 2024. doi:10.
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