Glycemic Control and Adult Height: A Nationwide Swedish Cohort Study on Childhood Type 1 Diabetes
Authors' conclusion
Poor glycemic control after the onset of type 1 diabetes, compared to optimal control, is associated with lower adult height in males and females. The prepubertal period seems to be more critical for females than males.
Study context
- Population
- All individuals with childhood-onset T1D in the Swedish National Diabetes Register
- Exposure
- Suboptimal and poor vs optimal glycemic control
- Outcome
- Final adult height and risk of short stature
Methodological detailsnationwide, National Diabetes Register
- Nationwide
- National Diabetes Register
Main finding
As reported in the abstract
Final adult height
Each group vs optimalEstimate (95% CI)
Poor
difference (males) −2.91 cm(−3.48 to −2.33)
Poor
difference (females) −1.83 cm(−2.42 to −1.23)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Short staturePoorvs Optimal | OR (males) 1.90 (CI 1.07–3.35) | |
| Short staturePoorvs Optimal | OR (females) 0.73 (CI 0.36–1.51) | |
| 0.20.5125Ratio (log scale) |
Timing of poor control and age at onset, by sex
- Females: adult height lower only with T1D since before puberty and poor control before puberty
- Males: adult height lower irrespective of age at onset, but only with poor control during or after puberty
Original publication
Glycemic Control and Adult Height: A Nationwide Swedish Cohort Study on Childhood Type 1 Diabetes. J Clin Endocrinol Metab. Published 18 November 2024. doi:10.
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