Imbalance of Myoinositol and D‐Chiro‐Inositol in Saliva of Children With Type‐1 Diabetes Mellitus: A Cross‐Sectional Study
Authors' conclusion
Children with DM-1 express higher MI and lower DCI levels, while non-diabetic children show an inversion of these concentrations. Inositol imbalance in saliva of diabetic children resembles previous results in urine, and represents a possible venue for monitoring this disease, paving the way for future investigations into salivary inositols.
Study context
- Population
- Children aged 3–12 years with T1D (fasting blood glucose >126 mg/dL, HbA1c >7%) and controls
- Participants
- 45 children
- Exposure
- Children with T1D vs controls
- Diabetes mellitus (DM-1)n = 25
- Controlsn = 20reference
- Outcome
- Salivary MI and DCI levels
Main finding
As reported in the abstract
Salivary MI, DCI and MI-DCI ratio
MI-DCI ratio elevated among diabetic children
16-fold
Myoinositol (MI) increased the odds of DM-1
174%
D-chiro- inositol (DCI) reduced the odds of DM-1
63%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Periodontal health: plaque and gingival bleedingDM-1 vs Controls · Plaque higher in DM-1 | P = 0.003 |
| Periodontal health: plaque and gingival bleedingDM-1 vs Controls · Gingival bleeding higher in DM-1 | P = 0.001 |
Original publication
Imbalance of Myoinositol and D‐Chiro‐Inositol in Saliva of Children With Type‐1 Diabetes Mellitus: A Cross‐Sectional Study. Clin Endocrinol (Oxf). Published 18 November 2024. doi:10.
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