Risk of renal complications and death in young and middle-aged Swedes with parental type 1 diabetes: a nation-wide, prospective cohort study
Authors' conclusion
Individuals with parental diabetes had slightly higher HbA1c and elevated risks of renal failure and death compared with those with sporadic diabetes, especially pronounced in women. Although the exact mechanisms behind these differences are unclear, we suggest that individualized care may benefit individuals with parental type 1 diabetes.
Study context
- Population
- Individuals with T1D onset before age 15, recorded 1977–2010 in the Swedish Childhood Diabetes Register15,701 with parental status
- Participants
- 16,572 individuals
- Exposure
- Parental T1D vs sporadic T1D
- Parental diabetesn = 1,390
- Outcome
- Mortality, renal failure and HbA1c
Methodological detailsnation-wide, registry linkage
- Nation-wide
- Registry linkage
Main finding
As reported in the abstract
Each group vs sporadic diabetesEstimate (95% CI)
Parental diabetes
HR (Cox) for death 1.33(1.00–1.75)
Parental diabetes
competing risk HR for renal failure 1.27(1.08–1.50)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Early death in womenWomen | 1.79 (1.17–2.72) | |
| 0.20.5125Hazard ratio (log scale) |
%
| Outcome | Parental diabetes | Sporadic diabetes | P value |
|---|---|---|---|
| HbA1c · 20-30 years of ageHigher with parental diabetes | 8.4 (68 mmol/mol) | 8.2 (66 mmol/mol) | P = 0.004 |
- HbA1c: HbA1c data in 9105 individuals
Original publication
Risk of renal complications and death in young and middle-aged Swedes with parental type 1 diabetes: a nation-wide, prospective cohort study. BMJ Open Diabetes Res Care. Published 21 January 2025. doi:10.
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