Metabolic Effects of Glucagon Stimulations in Type 1 Diabetes and Healthy Controls
Authors' conclusion
Generally, metabolic responses to glucagon stimulation in type 1 diabetes are similar to healthy controls. However, elevated glucose production was observed following the lowest glucagon dose in participants with type 1 diabetes compared with healthy controls, indicating enhanced glucagon sensitivity to low-dose glucagon stimulations.
Study context
- Population
- Participants with T1D and healthy controls
- Participants
- 29 participants
- Comparison
- T1D vs healthy controls
- T1Dn = 19
- Healthy controlsn = 10reference
- Outcome
- Metabolic responses to glucagon stimulation
Methodological detailshyperinsulinemic-euglycemic clamp with 5-stepwise ascending glucagon injections
- Hyperinsulinemic-euglycemic clamp with 5-stepwise ascending glucagon injections
Main finding
As reported in the abstract
- Series of incremental AUC of plasma glucose during glucagon injections did not differ between groups
- During first 10 μg glucagon injection, T1D had higher incremental AUC of plasma glucose than healthy controls
- Plasma nonesterified fatty acids, glycerol and metabolomic metabolites did not differ between groups
Further findings
Effect of hypoglycemia exposure in T1D
- Exposure to hypoglycemia did not impact glucagon-induced metabolic responses in T1D
Original publication
Metabolic Effects of Glucagon Stimulations in Type 1 Diabetes and Healthy Controls. J Clin Endocrinol Metab. Published 20 January 2025. doi:10.
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