Low LDL particle levels associate with coronary arteries free from atherosclerosis in long-term type 1 diabetes: the Dialong study
Authors' conclusion
In this cohort of long-term survivors of type 1 diabetes, lower levels of all types of LDL particles associated significantly with higher odds of having coronary arteries free from atherosclerosis, after adjustment for statin treatment. These results emphasize the importance of early treatment start and lipid management in the development of CAD in type 1 diabetes and suggest a subgroup of long-term survivors of type 1 diabetes to may hold environmental or genetic protective beneficial traits, independent of statin use. More research on the role of lipoproteins in the development of atherosclerosis in patients with type 1 diabetes is needed.
Study context
- Population
- Individuals with long-term T1D (mean age 62 years, diabetes duration 50.6 years) and control subjects; Computed tomography coronary angiography (CTCA) in those without previously established coronary heart disease
- Participants
- 102 vs 61
- Exposure
- T1D vs control subjects; LDL particle levels vs coronary arteries free from atherosclerosis
- Diabetesn = 102
- Controln = 61reference
- Outcome
- Coronary arteries free from atherosclerosis (CTCA) in association with nuclear magnetic resonance (NMR)-quantified lipoproteins and metabolites
Methodological detailscontrolled
- Controlled
Main finding
As reported in the abstract
- Lower particle concentration of all LDL subclass particles associated with higher odds of coronary arteries free from atherosclerosis
- p < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Particle concentration of IDL and all LDL and VLDL subclassesLower with Diabetes, independent of presence of CAD | P < 0.05 for all |
Normal Coronary Artery Calcium (CAC) score
- Low particle concentration of all LDL subclasses associated with normal CAC score
- P < 0.05 for all
- Adjusted for age, sex, BMI, eGFR and statin treatment
Original publication
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