International multicenter survey on screening and confirmatory testing in primary aldosteronism
Authors' conclusion
Diversity of the diagnostic steps may lead to an inconsistent diagnosis of PA among centers and limit comparison of evidence for PA between different centers. We expect the impact of this diversity to be most prominent in patients with mild PA. The survey raises 2 issues: the need for standardization of the diagnostic process and revisiting the concept of mild PA. Further standardization of the diagnostic process/criteria will improve the quality of evidence and management of patients with PA.
Study context
- Population
- Expert centers performing screening and confirmatory testing for primary aldosteronism (PA), 3 continents
- Participants
- 33 centers
- Outcome
- Diagnostic approaches for PA across centers
Methodological detailsinternational multicenter survey, Google questionnaires
- International multicenter survey
- Google questionnaires
Main finding
As reported in the abstract
- Prominent diversity in blood-sampling conditions, aldosterone and renin assay methods, and methods and diagnostic cutoffs for screening and confirmatory tests
- Most standard measures: modification of antihypertensive medication and sitting posture for blood sampling; Plasma aldosterone concentration (PAC) and active renin concentration by chemiluminescence enzyme immunoassay; ARR combined with PAC for screening; seated saline infusion test for confirmation
- Cutoff values for screening and confirmatory testing varied significantly among centers
Observational data: associations, not effects.
Original publication
International multicenter survey on screening and confirmatory testing in primary aldosteronism. Eur J Endocrinol. Published 13 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →