Effect of Oral Contraception on Screening Tests for Primary Aldosteronism: A 10-Year Longitudinal Study
Authors' conclusion
OC can increase the ARR and cause a false positive PA screening result. Until more reliable criteria for PA screening in OC users are established, alternative contraception should be considered during screening.
Study context
- Population
- Female offspring (Gen2) of women in the Raine Study with blood pressure (BP), blood samples and oral contraception (OC)-use information at age 17 and/or 27 years484 at 17 y
- Exposure
- OC users vs nonusers
- Outcome
- ARR (screening test for primary aldosteronism (PA))
- Follow-up
- 17 and 27 years
Methodological detailspopulation-based birth cohort (Raine Study)
- Population-based birth cohort (Raine Study)
Main finding
As reported in the abstract
OC users
31.5
Nonusers
18.3
Observational data: associations, not effects.
Further findings
Aldosterone concentration · 17 years
P < 0.001
Renin concentration · 17 years
Renin concentration · 27 years
ARR > 70 pmol/mU · 17 years
ARR > 70 pmol/mU · 27 years
| Outcome | OC users | Nonusers |
|---|---|---|
| ARR · 27 years | 27.3 | 21.1 |
Aldosterone to renin ratio (ARR) · 27 years
- ARR significantly higher in OC users vs nonusers
Renin concentration · 17 years
- Renin significantly lower in OC users
Renin concentration · 27 years
- Renin significantly lower in OC users
ARR > 70 pmol/mU · 17 years
- Significantly higher in OC users
ARR > 70 pmol/mU · 27 years
- Significantly higher in OC users; BP comparable to those with ARR < 70
ARR–BP relationship
- OC use at any age abolished the ARR–BP relationship seen in nonusers
Original publication
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