Partial pressure of oxygen-guided adrenal venous sampling in primary aldosteronism
Authors' conclusion
This is the first study to examine the pO2 dynamics in the human AV and non-AVs, demonstrating its potential to improve AVS cannulation success rates. Our findings also presented the oxygen consumption in the adrenal glands for steroidogenesis.
Study context
- Population
- Patients with primary aldosteronism (PA) who underwent adrenal venous sampling (AVS), 2021–2024168 received oxygen
- Participants
- 179 patients
- Outcome
- Distribution of pO2 in the AVs and neighboring veins (hepatic, inferior phrenic, external iliac)
Main finding
As reported in the abstract
pO2 distribution across veins (patients receiving oxygen supplementation) · baseline
- Pressure of oxygen (pO2) significantly higher in bilateral adrenal veins (AVs) than in HV and inferior phrenic veins at baseline
- Partial pressure of carbon dioxide lower in AVs
- After cosyntropin stimulation, AV pO2 decreased but distribution patterns across veins remained similar
- pO2 evaluation gave highly accurate identification of AVs before and after cosyntropin stimulation
Original publication
Partial pressure of oxygen-guided adrenal venous sampling in primary aldosteronism. J Clin Endocrinol Metab. Published 6 March 2026. doi:10.
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