Association of Posttreatment Blood Pressure Levels With Incident Stroke in Patients With Primary Aldosteronism: A Retrospective Cohort Study
Authors' conclusion
A target BP of <130/80 mmHg might be associated with a reduced risk of stroke in patients with PA.
Study context
- Population
- Patients with PA aged ≥30 years hospitalized at a hypertension center, January 2008–December 2019; median age 49 years, 55% male
- Participants
- 3,138 patients
- Exposure
- Mean follow-up blood pressure (BP) levels
- Outcome
- Incident stroke during follow-up
- Follow-up
- Median 6 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incident stroke
Hazard ratio (95% CI)P value
SBP <130 mmHgvs SBP ≥140 mmHgrisk decreased by 54%
0.46(0.26–0.80)
P = 0.006SBP 130-139 mmHgvs SBP ≥140 mmHgrisk decreased by 47%
0.53(0.33–0.84)
P = 0.007Mean SBP during follow-upadjusted; positive association
1.04(1.02–1.06)
P < 0.001Mean DBP during follow-upadjusted; positive association
1.05(1.01–1.08)
P = 0.005Observational data: associations, not effects.
Further findings
Subgroup and sensitivity analyses
- Association between mean follow-up systolic blood pressure (SBP) and stroke incidence remained consistent
Original publication
Association of Posttreatment Blood Pressure Levels With Incident Stroke in Patients With Primary Aldosteronism: A Retrospective Cohort Study. Endocr Pract. Published 30 January 2026. doi:10.
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